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Interventions For Improving Long Covid Symptomatology: A Systematic Review

journal contribution
posted on 2023-08-30, 20:12 authored by Nicola Veronese, Roberta Bonica, Sergio Cotugno, Ottavia Tulone, Michele Camporeale, Lee Smith, Mike Trott, Olivier Bruyere, Luigi Mirarchi, Giuseppina Rizzo, Davide Fiore Bavaro, Mario Barbagallo, Ligia Dominguez, Claudia Marotta, Andrea Silenzi, Emanuele Nicastri, Annalisa Saracino, Francesco Di Gennaro
Introduction: Although the understanding of several aspects of long COVID-19 syndrome is increasing, there is limited literature regarding the treatment of these signs and symptoms. The aim of our systematic review was to understand which therapies have proved effective against the symptoms of long COVID-19. Methods: A systematic search for randomized controlled or clinical trials in several databases was conducted through 15 May 2022. Specific inclusion criteria included: (1) intervention studies, either randomized controlled (RCTs) or clinical trials; (2) diagnosis of long COVID-19, according to the World Health Organization criteria; (3) presence of long COVID-19 for at least 12 weeks after SARS-CoV-2 infection. Results: We initially found 1638 articles to screen. After removing 1602 works based on their title/abstract, we considered 35 full texts, and among them, two intervention studies were finally included. The first RCT focused on the greater improvement of treatment combining olfactory rehabilitation with oral supplementation with Palmitoylethanolamide and Luteolin in patients with olfactory dysfunction after COVID-19. The second study evaluated the positive impact of aromatherapy vs. standard care in adult females affected by fatigue. Conclusion: Our systematic review found only two intervention studies focused on patients affected by long COVID-19. More intervention studies are needed to investigate potentially positive interventions for long COVID-19 symptoms.

History

Refereed

  • Yes

Volume

14

Issue number

9

Page range

1863

Publication title

Viruses

ISSN

1999-4915

Publisher

MDPI AG

File version

  • Accepted version

Language

  • eng

Legacy posted date

2022-08-24

Legacy creation date

2022-08-24

Legacy Faculty/School/Department

COVID-19 Research Collection

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