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Endostructural and periosteal growth of the human humerus

journal contribution
posted on 2023-08-31, 08:22 authored by Thomas G. O'Mahoney, Tristan Lowe, Andrew T. Chamberlain, William I. Sellers
The growth and development of long bones are of considerable interests in the fields of comparative anatomy and palaeoanthropology, as evolutionary changes and adaptations to specific physical activity patterns are expected to be revealed during bone ontogeny. Traditionally, the cross-sectional geometry of long bones has been examined at discrete locations usually placed at set intervals or fixed percentage distances along the midline axis of the bone shaft. More recently, the technique of morphometric mapping has enabled the continuous analysis of shape variation along the shaft. Here we extend this technique to the full sequence of late foetal and postnatal development of the humeral shaft in a modern human population sample, with the aim of establishing the shape changes during growth and their relationship with the development of the arm musculature and activity patterns. A sample of modern human humeri from individuals ranging in age from 24 weeks in-utero through to 18 years was imaged using microtomography at multiple resolutions and custom Matlab scripts. Standard biomechanical properties, cortical thickness, surface curvature and pseudo-landmarks were extracted along radial vectors spaced at intervals of 1° at each 0.5% longitudinal increment measured along the shaft axis. Heat maps were also generated for cortical thickness and surface curvature. The results demonstrate that a whole bone approach to analysis of cross-sectional geometry is more desirable where possible, as there is a continuous pattern of variation along the shaft. It is also possible to discriminate very young individuals and adolescents from other groups by relative cortical thickness, and also by periosteal surface curvature.

History

Refereed

  • Yes

Volume

0

Issue number

0

Page range

0

Publication title

The Anatomical Record

ISSN

1932-8494

Publisher

Wiley

File version

  • Accepted version

Language

  • eng

Legacy posted date

2022-08-03

Legacy creation date

2022-08-03

Legacy Faculty/School/Department

Faculty of Science & Engineering

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