The role of YKL-40 in the pathogenesis of autoimmune diseases: a comprehensive review

Tizaoui, Kalthoum and Yang, Jae Won and Lee, Keum Hwa and Kim, Ji Hong and Kim, Minseok and Yoon, Sojung and Jung, Yeonwoo and Park, Joon Beom and An, Kitae and Choi, Hyeok and Song, Donggyu and Jung, Hyun Taek and Ahn, Seongmin and Yuh, Taeho and Choi, Hee Min and Ahn, Jae Ha and Kim, Younjoung and Jee, Sanghyun and Lee, Hyeongsun and Jin, Soohwa and Kang, Jun-Gu and Koo, Bohyun and Lee, Joo Yeop and Min, Kyoung and Yoo, Wonseok and Rhyu, Hyeong Jun and Yoon, Yeonjung and Lee, Min Ho and Kim, Sung Eun and Hwang, Jimin and Koyanagi, Ai and Jacob, Louis and Park, Seoyeon and Shin, Jae Il and Smith, Lee (2022) The role of YKL-40 in the pathogenesis of autoimmune diseases: a comprehensive review. International Journal of Biological Sciences, 18 (9). pp. 3731-3746. ISSN 1449-2288

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Official URL: http://dx.doi.org/10.7150/ijbs.67587

Abstract

YKL-40, a chitinase-3-like protein 1 (CHI3L1) or human cartilage glycoprotein 39 (HC gp-39), is expressed and secreted by various cell-types including macrophages, chondrocytes, fibroblast-like synovial cells and vascular smooth muscle cells. Its biological function is not well elucidated, but it is speculated to have some connection with inflammatory reactions and autoimmune diseases. Although having important biological roles in autoimmunity, there were only attempts to elucidate relationships of YKL-40 with a single or couple of diseases in the literature. Therefore, in order to analyze the relationship between YKL-40 and the overall diseases, we reviewed 51 articles that discussed the association of YKL-40 with rheumatoid arthritis, psoriasis, systemic lupus erythematosus, Behçet disease and inflammatory bowel disease. Several studies showed that YKL-40 could be assumed as a marker for disease diagnosis, prognosis, disease activity and severity. It is also shown to be involved in response to disease treatment. However, other studies showed controversial results particularly in the case of Behçet disease activity. Therefore, further studies are needed to elucidate the exact role of YKL-40 in autoimmunity and to investigate its potential in therapeutics.

Item Type: Journal Article
Keywords: YKL-40, Autoimmune disease, Biomarker, Disease, Pathogenesis, Diagnostic marker
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 23 May 2022 10:45
Last Modified: 31 May 2022 16:17
URI: https://arro.anglia.ac.uk/id/eprint/707620

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