Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota

Bloor, Sarah R. and Schutte, Rudolph and Hobson, Anthony R. (2021) Oral Iron Supplementation—Gastrointestinal Side Effects and the Impact on the Gut Microbiota. Microbiology Research, 12 (2). pp. 491-502. ISSN 2036-7481

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Official URL: https://doi.org/10.3390/microbiolres12020033


Iron deficiency anaemia (IDA) is a worldwide healthcare problem affecting approximately 25% of the global population. The most common IDA treatment is oral iron supplementation, which has been associated with gastrointestinal (GI) side effects such as constipation and bloating. These can result in treatment non-adherence and the persistence of IDA. Intravenous iron does not cause GI side effects, which may be due to the lack of exposure to the intestinal lumen. Luminal iron can cause changes to the gut microbiota, aiding the promotion of pathogenic species and decreasing beneficial protective species. Iron is vital for methanogenic archaea, which rely on iron for growth and metabolism. Increased intestinal methane has been associated with slowing of intestinal transit, constipation, and bloating. Here we explore the literature to understand a potential link between iron and methanogenesis as a novel way to understand the mechanism of oral iron supplementation induced GI side effects.

Item Type: Journal Article
Keywords: iron, constipation, bloating, methane, methanogens, gut microbiota
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Lisa Blanshard
Date Deposited: 16 May 2022 15:52
Last Modified: 31 May 2022 16:18
URI: https://arro.anglia.ac.uk/id/eprint/707591

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