Incidence, prevalence, and global burden of autism spectrum disorder from 1990 to 2019 across 204 countries

Solmi, Marco and Song, Minjin and Yon, Dong Keon and Lee, Seung Won and Fombonne, Eric and Kim, Min Seo and Park, Seoyeon and Lee, Min Ho and Hwang, Jimin and Keller, Roberto and Koyanagi, Ai and Jacob, Louis and Dragioti, Elena and Smith, Lee and Correll, Christopher and Fusar-Poli, Paolo and Croatto, Giovanni and Carvalho, Andre F. and Oh, Jae Won and Lee, San and Gosling, Corentin and Cheon, Keun-Ah and Mavridis, Dimitris and Chu, Che-Sheng and Liang, Chih-Sung and Radua, Joaquim and Boyer, Laurent and Fond, Guillaume and Shin, Jae Il and Cortese, Samuele (2022) Incidence, prevalence, and global burden of autism spectrum disorder from 1990 to 2019 across 204 countries. Molecular Psychiatry. ISSN 1476-5578

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Official URL: https://doi.org/10.1038/s41380-022-01630-7

Abstract

Autism spectrum disorder (ASD) substantially contributes to the burden of mental disorders. Improved awareness and changes in diagnostic criteria of ASD may have influenced the diagnostic rates of ASD. However, while data on trends in diagnostic rates in some individual countries have been published, updated estimates of diagnostic rate trends and ASD-related disability at the global level are lacking. Here, we used the Global Burden of Diseases, Injuries, and Risk Factors Study data to address this gap, focusing on changes in prevalence, incidence, and disability-adjusted life years (DALYs) of ASD across the world. From 1990 to 2019, overall age-standardized estimates remained stable globally. Both prevalence and DALYs increased in countries with high socio-demographic index (SDI). However, the age-standardized incidence decreased in some low SDI countries, indicating a need to improve awareness. The male/female ratio decreased between 1990 and 2019, possibly accounted for by increasing clinical attention to ASD in females. Our results suggest that ASD detection in low SDI countries is suboptimal, and that ASD prevention/treatment in countries with high SDI should be improved, considering the increasing prevalence of the disorder. Additionally, growing attention is being paid to ASD diagnosis in females, who might have been left behind by ASD epidemiologic and clinical research previously. ASD burden estimates are underestimated as GBD does not account for mortality in ASD.

Item Type: Journal Article
Keywords: GBD, Autism, Epidemiology, Autism spectrum disorders, Psychiatric disorders
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 16 May 2022 10:02
Last Modified: 08 Jul 2022 09:13
URI: https://arro.anglia.ac.uk/id/eprint/707577

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