Sex-differential associations between body mass index and the incidence of dementia

Jacob, Louis, Smith, Lee, Koyanagi, Ai, Konrad, Marcel, Haro, Josep M., Shin, Jae Il and Kostev, Karel (2022) Sex-differential associations between body mass index and the incidence of dementia. Journal of Alzheimer's Disease, 88 (2). pp. 631-639. ISSN 1387-2877

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Abstract

Background:Little is known about the sex differences in the association between body mass index (BMI) and dementia in late life. Objective:Therefore, this retrospective cohort study aimed to analyze associations between BMI and dementia in older women and men separately in general practices in Germany. Methods:This study included patients followed in one of 832 general practices in Germany between 2006 and 2019 (index date: first visit date). Study variables included dementia (dependent variable), BMI (independent variable), age, sex, and comorbidities (control variables). Kaplan-Meier curves and adjusted Cox regression analyses were conducted to analyze associations between BMI and the 10-year incidence of dementia in women and men, separately. Results:There were 296,767 patients included in this study (mean [standard deviation] age 70.2 [5.9] years; 54.3% women). The proportion of underweight, normal weight, overweight, and obesity was 0.9%, 25.5%, 41.5%, and 32.1%, respectively. The 10-year incidence of dementia significantly decreased with increasing BMI, from 11.5% in women with underweight to 9.1% in those with obesity (log-rank p < 0.001). Respective figures in men were 12.0% and 8.2% (log-rank p < 0.001). In women, only overweight (versus normal weight) was significantly associated with dementia (HR = 0.93, 95% CI = 0.88–0.97). In contrast, in men, the only BMI category significantly associated with the incidence of dementia was underweight (HR = 1.58, 95% CI = 1.11–2.25). Conclusion:In this study conducted in Germany, overweight was negatively associated with dementia in women, whereas there was a positive underweight-dementia relationship in men. More data are needed to confirm or refute these findings in other settings.

Item Type: Journal Article
Keywords: Sex differences, Body mass Index, Dementia
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 05 May 2022 07:37
Last Modified: 17 Aug 2022 11:38
URI: https://arro.anglia.ac.uk/id/eprint/707553

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