The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability

Samvelyan, Hasmik J., Huesa, Carmen, Cui, Lin, Farquharson, Colin and Staines, Katherine A. (2022) The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability. Bone & Joint Research, 11 (3). pp. 162-170. ISSN 2046-3758

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Aims- Osteoarthritis (OA) is the most prevalent systemic musculoskeletal disorder, characterized by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here, we sought to examine the contribution of accelerated growth to OA development using a murine model of excessive longitudinal growth. Suppressor of cytokine signalling 2 (SOCS2) is a negative regulator of growth hormone (GH) signalling, thus mice deficient in SOCS2 (Socs2-/-) display accelerated bone growth. Methods- We examined vulnerability of Socs2-/- mice to OA following surgical induction of disease (destabilization of the medial meniscus (DMM)), and with ageing, by histology and micro-CT. Results- We observed a significant increase in mean number (wild-type (WT) DMM: 532 (SD 56); WT sham: 495 (SD 45); knockout (KO) DMM: 169 (SD 49); KO sham: 187 (SD 56); p < 0.001) and density (WT DMM: 2.2 (SD 0.9); WT sham: 1.2 (SD 0.5); KO DMM: 13.0 (SD 0.5); KO sham: 14.4 (SD 0.7)) of growth plate bridges in Socs2-/- in comparison with WT. Histological examination of WT and Socs2-/- knees revealed articular cartilage damage with DMM in comparison to sham. Articular cartilage lesion severity scores (mean and maximum) were similar in WT and Socs2-/- mice with either DMM, or with ageing. Micro-CT analysis revealed significant decreases in SCB thickness, epiphyseal trabecular number, and thickness in the medial compartment of Socs2-/-, in comparison with WT (p < 0.001). DMM had no effect on the SCB thickness in comparison with sham in either genotype. Conclusion- Together, these data suggest that enhanced GH signalling through SOCS2 deletion accelerates growth plate fusion, however this has no effect on OA vulnerability in this model.

Item Type: Journal Article
Keywords: osteoarthritis, SOCS2, cartilage, growth plate, bone, growth hormone, articular cartilage lesions, micro-CT scans, articular cartilage damage, subchondral bone, destabilization of the medial meniscus (DMM), murine model, bone growth, cytokine
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Lisa Blanshard
Date Deposited: 04 May 2022 08:19
Last Modified: 07 Jun 2022 14:12

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