Physical multimorbidity predicts the onset and persistence of anxiety: a prospective analysis of the Irish Longitudinal Study on Ageing

Smith, Lee and Shin, Jae Il and Jacob, Louis and Schuch, Felipe B. and Pizzol, Damiano and López-Sánchez, Guillermo F. and Soysal, Pinar and Tully, Mark A. and Butler, Laurie T. and Barnett, Yvonne A. and Veronese, Nicola and Park, Seoyeon and Koyanagi, Ai (2022) Physical multimorbidity predicts the onset and persistence of anxiety: a prospective analysis of the Irish Longitudinal Study on Ageing. Journal of Affective Disorders, 309. pp. 71-76. ISSN 1573-2517

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Official URL: https://doi.org/10.1016/j.jad.2022.04.022

Abstract

Background- The aims of the present study were to examine prospective associations of multimorbidity (i.e., ≥2 chronic conditions) at baseline with incident and persistent anxiety over a two-year follow-up period among Irish older adults, and to quantify the extent to which sleep, pain, and disability mediate the multimorbidity-anxiety relationship. Methods- Data from The Irish Longitudinal Study on Aging (TILDA) conducted between 2009 and 2011 with a follow-up after two years were analyzed. Anxiety referred to score ≥ 8 on the anxiety section of the Hospital Anxiety and Depression Scale. Lifetime diagnosis of 14 chronic conditions was obtained. Outcomes were incident and persistent anxiety at two-year follow-up. Results- Data on 5871 adults aged ≥50 years at baseline were analyzed [Mean (SD) age 63.3 (9.0) years; 51.2% women]. After adjustment for potential confounders, compared to no chronic physical conditions at baseline, ≥3 chronic conditions were associated with a significant 1.89 (95% CI = 1.16–3.08) times higher risk for new onset anxiety at follow-up. Furthermore, having 1, 2, and ≥3 conditions at baseline were associated with significant 1.48 (95% CI 1.02, 2.14), 1.74 (95% CI 1.19, 2.53), and 1.84 (95% CI 1.27, 2.68) times higher risk for persistent anxiety at follow-up. Sleep problems, pain, and disability were identified as significant mediators, explaining 22.9%–37.8% of the associations. Conclusion- Multimorbidity was associated with both new onset and persistent anxiety among Irish older adults. Future interventional studies should examine whether addressing the identified mediators may lead to lower risk for incident or persistent anxiety among those with physical multimorbidity.

Item Type: Journal Article
Keywords: Multimorbidity, Anxiety, Older Adults, Cohort, Epidemiology
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 12 Apr 2022 16:26
Last Modified: 31 May 2022 16:17
URI: https://arro.anglia.ac.uk/id/eprint/707470

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