Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials

Lim, Soojin and Park, Seoyeon and Koyanagi, Ai and Yang, Jae Won and Jacob, Louis and Yon, Dong Keon and Lee, Seung Won and Kim, Min Seo and Shin, Jae Il and Smith, Lee (2022) Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials. Pharmacological Research, 176. p. 106052. ISSN 1043-6618

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Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

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Official URL: https://doi.org/10.1016/j.phrs.2021.106052

Abstract

Various melatonin supplementations have been developed to improve health outcomes in various clinical conditions. Thus, we sought to evaluate and summarize the effect of melatonin treatments in clinical settings for health outcomes. We searched PubMed/Medline, Embase, and Cochrane Library from inception to 4 February 2021. We included meta-analyses of randomized controlled trials investigating the melatonin intervention for any health outcome. Based on the different effect sizes of each meta-analysis, we calculated random models' standardized mean differences or risk ratios. We observed robust evidence supported by statistical significance with non-considerable heterogeneity between studies for sleep-related problems, cancer, surgical patients, and pregnant women. Patients with sleep disorder, sleep onset latency (SMD 0.33, 95% CI: 0.10 – 0.56, P < 0.01) were significantly improved whereas no clear evidence was shown with sleep efficiency (1.10, 95% CI: −0.26 to 2.45). The first analgesic requirement time (SMD 5.81, 95% CI: 2.57–9.05, P < 0.001) of surgical patients was distinctly improved. Female patients under artificial reproductive technologies had significant increase in the top-quality embryos (SMD 0.53, 95% CI: 0.27 – 0.79, P < 0.001), but no statistically clear evidence was found in the live birth rate (SMD 1.20, 95% CI: 0.83 – 1.72). Survival at one year (RR 1.90, 95% CI: 1.28 – 2.83, P < 0.005) significantly increased with cancer patients. Research on melatonin interventions to treat clinical symptoms and sleep problems among diverse health conditions was identified and provided considerable evidence. Future well-designed randomized clinical trials of high quality and subgroup quantitative analyses are essential.

Item Type: Journal Article
Keywords: Melatonin, Umbrella review, Randomized controlled trial, Clinical outcome
Faculty: Faculty of Science & Engineering
Depositing User: Lisa Blanshard
Date Deposited: 17 Mar 2022 13:28
Last Modified: 31 May 2022 16:18
URI: https://arro.anglia.ac.uk/id/eprint/707412

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