Colorectal liver metastasis: molecular mechanism and interventional therapy

Zhou, Hui, Liu, Zhongtao, Wang, Yongxiang, Wen, Xiaoyong, Amador, Eric H., Yuan, Liqin, Ran, Xin, Xiong, Li, Ran, Yuping, Chen, Wei and Wen, Yu (2022) Colorectal liver metastasis: molecular mechanism and interventional therapy. Signal Transduction and Targeted Therapy, 7 (1). p. 70. ISSN 2059-3635

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Official URL: https://doi.org/10.1038/s41392-022-00922-2

Abstract

Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

Item Type: Journal Article
Keywords: Cancer, Metastasis
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Lisa Blanshard
Date Deposited: 16 Mar 2022 17:03
Last Modified: 31 May 2022 16:18
URI: https://arro.anglia.ac.uk/id/eprint/707408

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