Zhou_et_al_2022.pdf (2.69 MB)
Colorectal liver metastasis: molecular mechanism and interventional therapy
journal contribution
posted on 2023-07-26, 15:43 authored by Hui Zhou, Zhongtao Liu, Yongxiang Wang, Xiaoyong Wen, Eric H. Amador, Liqin Yuan, Xin Ran, Li Xiong, Yuping Ran, Wei Chen, Yu WenColorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.
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Refereed
- Yes
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7Issue number
1Page range
70Publication title
Signal Transduction and Targeted TherapyISSN
2059-3635External DOI
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SpringerFile version
- Published version
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- eng
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2022-03-16Legacy creation date
2022-03-16Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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