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Colorectal liver metastasis: molecular mechanism and interventional therapy

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posted on 2023-07-26, 15:43 authored by Hui Zhou, Zhongtao Liu, Yongxiang Wang, Xiaoyong Wen, Eric H. Amador, Liqin Yuan, Xin Ran, Li Xiong, Yuping Ran, Wei Chen, Yu Wen
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver metastasis, which is the major cause of death. Despite significant advances in diagnostic and therapeutic techniques, the survival rate of colorectal liver metastasis (CRLM) patients remains very low. CRLM, as a complex cascade reaction process involving multiple factors and procedures, has complex and diverse molecular mechanisms. In this review, we summarize the mechanisms/pathophysiology, diagnosis, treatment of CRLM. We also focus on an overview of the recent advances in understanding the molecular basis of CRLM with a special emphasis on tumor microenvironment and promise of newer targeted therapies for CRLM, further improving the prognosis of CRLM patients.

History

Refereed

  • Yes

Volume

7

Issue number

1

Page range

70

Publication title

Signal Transduction and Targeted Therapy

ISSN

2059-3635

Publisher

Springer

File version

  • Published version

Language

  • eng

Legacy posted date

2022-03-16

Legacy creation date

2022-03-16

Legacy Faculty/School/Department

Faculty of Health, Education, Medicine & Social Care

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