Manyonda, Isaac, Sinai Talaulikar, Vikram, Pirhadi, Roxanna, Ward, John, Banerjee, Dibyesh and Onwude, Joseph (2022) Could Perimenopausal Estrogen Prevent Breast Cancer? Exploring the Differential Effects of Estrogen-Only Versus Combined Hormone Replacement Therapy. Journal of Clinical Medicine Research, 14 (1). pp. 1-7. ISSN 1918-3011
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Abstract
Breast cancer is the commonest cancer among women in the western world, accounting for up to 30% of all cancers in women. There is a long-standing controversy about the potential link to hormone replacement therapy (HRT), with large observational studies suggesting that HRT increases the risk, while the Women’s Health Initiative (WHI), a prospective, randomized placebo-controlled trial, has reported several times over a period of 20 years that combined (estrogen and progestogen) HRT increases the risk, while estrogen-only HRT given to women who have had a prior hysterectomy, is associated with a significantly reduced risk of developing breast cancer. Evidence from the randomized trial shows a significant reduction in both incidence of and mortality from breast cancer in women who took estrogen replacement therapy; this message needs to be presented clearly and robustly so that it can help women with decision making when considering HRT for menopause.
| Item Type: | Journal Article |
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| Keywords: | Menopause, HRT, Regimens |
| Faculty: | Faculty of Health, Education, Medicine & Social Care |
| Depositing User: | Lisa Blanshard |
| Date Deposited: | 08 Mar 2022 16:28 |
| Last Modified: | 16 Mar 2022 16:21 |
| URI: | https://arro.anglia.ac.uk/id/eprint/707385 |
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