Manyonda_et_al_2022.pdf (1 MB)
Could Perimenopausal Estrogen Prevent Breast Cancer? Exploring the Differential Effects of Estrogen-Only Versus Combined Hormone Replacement Therapy
journal contribution
posted on 2023-07-26, 15:42 authored by Isaac Manyonda, Vikram Sinai Talaulikar, Roxanna Pirhadi, John Ward, Dibyesh Banerjee, Joseph OnwudeBreast cancer is the commonest cancer among women in the western world, accounting for up to 30% of all cancers in women. There is a long-standing controversy about the potential link to hormone replacement therapy (HRT), with large observational studies suggesting that HRT increases the risk, while the Women’s Health Initiative (WHI), a prospective, randomized placebo-controlled trial, has reported several times over a period of 20 years that combined (estrogen and progestogen) HRT increases the risk, while estrogen-only HRT given to women who have had a prior hysterectomy, is associated with a significantly reduced risk of developing breast cancer. Evidence from the randomized trial shows a significant reduction in both incidence of and mortality from breast cancer in women who took estrogen replacement therapy; this message needs to be presented clearly and robustly so that it can help women with decision making when considering HRT for menopause.
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Refereed
- Yes
Volume
14Issue number
1Page range
1-7Publication title
Journal of Clinical Medicine ResearchISSN
1918-3011External DOI
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Elmer PressFile version
- Published version
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- eng
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2022-03-08Legacy creation date
2022-03-08Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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