Scotopic microperimetry: evolution, applications and future directions

Taylor, Laura J., Josan, Amandeep S., Pfau, Maximilian, Simunovic, Matthew P. and Jolly, Jasleen K. (2022) Scotopic microperimetry: evolution, applications and future directions. Clinical and Experimental Optometry. ISSN 1444-0938

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For many inherited and acquired retinal diseases, reduced night vision is a primary symptom. Despite this, the clinical testing options for spatially-resolved scotopic vision have until recently been limited. Scotopic microperimetry is a relatively new visual function test that combines two-colour perimetry with fundus-controlled perimetry performed in scotopic luminance conditions. The technique enables spatially-resolved mapping of central retinal sensitivity alongside the ability to distinguish between rod and cone photoreceptor sensitivities. Two companies produce commercially available scotopic microperimeters – Nidek (Nidek Technologies Srl, Padova, Italy) and CenterVue (CenterVue S.p.A., Padova, Italy). Scotopic microperimetry is a promising technology capable of detecting changes in retinal sensitivity before changes in other measures of visual function. Scotopic microperimetry is a promising functional biomarker that has potential as a useful clinical trial outcome measure. In this review, we summarise the evolution and applications of scotopic microperimetry, discuss testing options, including testing grid selection and dark-adaptation time and threshold sensitivity analyses.

Item Type: Journal Article
Keywords: scotopic microperimetry, microperimetry, fundus-controlled perimetry, rods, dark-adapted
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Ian Walker
Date Deposited: 14 Jan 2022 15:25
Last Modified: 13 Jan 2023 02:02

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