Jolly_et_al_2021.pdf (2.64 MB)
Structural and Functional Characteristics of Color Vision Changes in Choroideremia
journal contribution
posted on 2023-07-26, 15:37 authored by Jasleen K. Jolly, Matthew P. Simunovic, Adam M. Dubis, Amandeep S. Josan, Anthony G. Robson, Marco P. Bellini, Edward Bloch, Odysseas Georgiadis, Lyndon da Cruz, Holly Bridge, Robert E. MacLarenColor vision is considered a marker of cone function and its assessment in patients with retinal pathology is complementary to the assessments of spatial vision [best-corrected visual acuity (BCVA)] and contrast detection (perimetry). Rod-cone and chorioretinal dystrophies—such as choroideremia—typically cause alterations to color vision, making its assessment a potential outcome measure in clinical trials. However, clinical evaluation of color vision may be compromised by pathological changes to spatial vision and the visual field. The low vision Cambridge Color Test (lvCCT) was developed specifically to address these latter issues. We used the trivector version of the lvCCT to quantify color discrimination in a cohort of 53 patients with choroideremia. This test enables rapid and precise characterization of color discrimination along protan, deutan, and tritan axes more reliably than the historically preferred test for clinical trials, namely the Farnsworth Munsell 100 Hue test. The lvCCT demonstrates that color vision defects—particularly along the tritan axis—are seen early in choroideremia, and that this occurs independent of changes in visual acuity, pattern electroretinography and ellipsoid zone area on optical coherence tomography (OCT). We argue that the selective loss of tritan color discrimination can be explained by our current understanding of the machinery of color vision and the pathophysiology of choroideremia.
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Refereed
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15Page range
729807Publication title
Frontiers in NeuroscienceISSN
1662-453XExternal DOI
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Frontiers MediaFile version
- Published version
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- eng
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2021-12-14Legacy creation date
2021-12-14Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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