Body mass index and mild cognitive impairment among middle-aged and older adults from low- and middle-income countries

Smith, Lee and Oh, Hans and Carmichael, Christina and Jacob, Louise and Stefanac, Sinisa and Lindsay, Rosie and Soysal, Pinar and Veronese, Nicola and Tully, Mark A. and Butler, Laurie T. and Barnett, Yvonne A. and Koyanagi, Ai (2021) Body mass index and mild cognitive impairment among middle-aged and older adults from low- and middle-income countries. Journal of Alzheimer's Disease. ISSN 1387-2877

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Official URL: http://dx.doi.org/10.3233/JAD-215345

Abstract

Background: The effect of weight modification on future dementia risk is currently a subject of debate and may be modified by age. Objective: The aim of the present study was to investigate the association between body mass index (BMI) status with mild cognitive impairment (MCI) (a preclinical stage of dementia) in middle-aged and older adults residing in six low- and middle-income countries using nationally representative data. Methods: Cross-sectional data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. MCI was defined using the National Institute on Aging-Alzheimer’s Association criteria. BMI (kg/m2) was based on measured weight and height and categorized as: underweight (<18.5), normal (18.5–24.9), overweight (25.0–29.9), and obese (≥30.0). Multivariable logistic regression analysis and meta-analysis were conducted to assess associations. Results: Data on 32,715 individuals aged ≥50 years with preservation in functional abilities were analyzed [mean (SD) age 62.1 (15.6) years; 51.7% females]. Among those aged 50–64 years, compared to normal weight, underweight (OR = 1.44; 95% CI = 1.14–1.81), overweight (OR = 1.17; 95% CI = 1.002–1.37), and obesity (OR = 1.46; 95% CI = 1.09–1.94) were all significantly associated with higher odds for MCI. In those aged ≥65 years, underweight (OR = 0.71; 95% CI = 0.54–0.95) and overweight (OR = 0.72; 95% CI = 0.55–0.94) were associated with significantly lower odds for MCI, while obesity was not significantly associated with MCI. Conclusion: The results of the study suggest that the association between BMI and MCI is likely moderated by age. Future longitudinal studies are required to confirm or refute the present findings before recommendations for policy and practice can be made.

Item Type: Journal Article
Keywords: BMI, MCI, LMIC, Epidemiology
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 01 Nov 2021 10:02
Last Modified: 17 Jan 2022 15:22
URI: https://arro.anglia.ac.uk/id/eprint/707065

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