Natural course of Lid Wiper Epitheliopathy (LWE) in symptomatic contact lens wearers

Lievens, Chris, Norgett, Yvonne, Briggs, Nancy, Allen, Peter M. and Vianya-Estopa, Marta (2022) Natural course of Lid Wiper Epitheliopathy (LWE) in symptomatic contact lens wearers. Contact Lens and Anterior Eye, 45 (1). p. 101529. ISSN 1476-5411

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Abstract

Purpose- To establish the time course of lid wiper epitheliopathy (LWE) in established CL wearers after a single day (6–10 h) of daily disposable contact lens (CL) wear, the following day post-CL removal and 1-week after CL discontinuation. Methods- Twenty-one symptomatic (CLDEQ-8 score ≥ 12) habitual wearers of MyDay® silicone hydrogel daily disposable were included. LWE staining was assessed prior to CL wear (Visit 1, V1) using semi-automated analysis after instillation of two drops of 1 % lissamine green (10 μL) that were applied to the superior bulbar conjunctiva. LWE measurements were repeated after 6–10 h of continuous CL wear (Visit 2, V2), post-CL removal the following day (Visit 3, V3) and after 1-week CL discontinuation (Visit 4, V4). At each visit, ocular symptoms were evaluated using the SPEED-8 questionnaire and set of 0–100 visual analogue scales (VAS). Results- LWE showed no significant changes after 6–10 h of continuous CL wear (p = 0.536), post-CL removal the following day (p = 0.677) or following 1-week of CL discontinuation (p = 0.478). Analysis revealed a significant improvement in symptomatology between V1 and V2 (SPEED-8, p < 0.01) and also improvements in the 0–100 VAS scores between V2 and V4 for average daily dryness (p < 0.01), end-of-day dryness (p < 0.01) and frequency of end-of-day dryness (p < 0.05). Conclusion- The present data suggest that the etiology of LWE is multifactorial and the sole intervention of temporarily discontinuing CL wear does not lead to resolution of these clinical signs.

Item Type:	Journal Article
Keywords:	Lid Wiper Epitheliopathy, Dry Eye, Lissamine Green, Soft Contact Lens
Faculty:	Faculty of Science & Engineering
Depositing User:	Ian Walker
Date Deposited:	21 Oct 2021 13:28
Last Modified:	26 Oct 2022 01:02
URI:	https://arro.anglia.ac.uk/id/eprint/707042

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