Prevalence of unwillingness and uncertainty to vaccinate against COVID-19 in older people: a systematic review and meta-analysis

Veronese, Nicola and Saccaro, Carlo and Demurtas, Jacopo and Smith, Lee and Dominguez, Ligia and Maggi, Stefania and Barbagallo, Mario (2021) Prevalence of unwillingness and uncertainty to vaccinate against COVID-19 in older people: a systematic review and meta-analysis. Ageing Research Reviews, 72. p. 101489. ISSN 1872-9649

[img] Text
Accepted Version
Restricted to Repository staff only until 15 October 2022.
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (533kB)
[img] Text (Word version)
Accepted Version
Restricted to Repository staff only until 15 October 2022.
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (335kB)
Official URL: https://doi.org/10.1016/j.arr.2021.101489

Abstract

The coronavirus disease 2019 (COVID-19) has been shown to have more severe health outcomes in older people specifically in relation to mortality and disability. Vaccination seems to be efficacious and safe for preventing the negative consequences of COVID-19, but vaccine hesitancy seems to be high in older adults. We therefore aimed to investigate the prevalence of unwillingness and the uncertainty to vaccinate against COVID-19 in older people and the factors that can be associated with the unwillingness to vaccinate. For this work, we searched several databases until 18th June 2021 for studies reporting the prevalence of unwillingness and the uncertainty to vaccinate against COVID-19 in people aged >60 years. A meta-analysis of the prevalence, with the correspondent 95% confidence intervals (CIs), was proposed. Factors that can be associated with the unwillingness to vaccinate against COVID-19 were explored through multivariable analyses and reported as odds ratios (ORs). Among 662 papers initially screened, we included 15 studies for a total of 9753 older adults. The prevalence of unwillingness to vaccinate against COVID-19 in older people was 27.03% (95%CI: 15.10–38.95%), whilst the correspondent figure of uncertainty was 19.33% (95%CI: 12.28–26.39). The risk of being unvaccinated was significantly higher in Hispanics (OR=1.197; 95%CI: 1.010–1.418) and in case of low education (OR=1.678; 95%CI: 1.170–2.408) and low income (OR=1.287; 95%CI: 1.127–1.469). In conclusion, the hesitancy for COVID-19 vaccination is a relevant problem in older people, particularly in those with a low income, a low level of education, and in Hispanics living in the United States.

Item Type: Journal Article
Keywords: Vaccine hesitancy, COVID-19, Older adults, Review
Faculty: COVID-19 Research Collection
Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 18 Oct 2021 10:16
Last Modified: 02 Nov 2021 10:27
URI: https://arro.anglia.ac.uk/id/eprint/707020

Actions (login required)

Edit Item Edit Item