Battista_et_al_2021.pdf (935.94 kB)
The Use of Botulinum Toxin A as an Adjunctive Therapy in the Management of Chronic Musculoskeletal Pain: A Systematic Review with Meta-Analysis
journal contribution
posted on 2023-07-26, 15:32 authored by Simone Battista, Luca Buzzatti, Marialuisa Gandolfi, Cinzia Finocchi, Luca Falsiroli Maistrello, Antonello Viceconti, Benedetto Giardulli, Marco TestaSeveral studies have investigated the effect of botulinum toxin A (BoNT-A) for managing chronic musculoskeletal pain, bringing contrasting results to the forefront. Thus far, however, there has been no synthesis of evidence on the effect of BoNT-A as an adjunctive treatment within a multimodal approach. Hence, Medline via PubMed, EMBASE, and the Cochrane Library-CENTRAL were searched until November 2020 for randomised controlled trials (RCTs) that investigated the use of BoNT-A as an adjunctive therapy for chronic musculoskeletal pain. The risk of bias (RoB) and the overall quality of the studies were assessed through RoB 2.0 and the GRADE approach, respectively. Meta-analysis was conducted to analyse the pooled results of the six included RCTs. Four were at a low RoB, while two were at a high RoB. The meta-analysis showed that BoNT-A as an adjunctive therapy did not significantly decrease pain compared to the sole use of traditional treatment (SDM −0.89; 95% CI −1.91; 0.12; p = 0.08). Caution should be used when interpreting such results, since the studies displayed very high heterogeneity (I = 94%, p < 0.001). The overall certainty of the evidence was very low. The data retrieved from this systematic review do not support the use of BoNT-A as an adjunctive therapy in treating chronic musculoskeletal pain.
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Refereed
- Yes
Volume
13Issue number
9Page range
640Publication title
ToxinsISSN
2072-6651External DOI
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MDPIFile version
- Published version
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- eng
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2021-09-28Legacy creation date
2021-09-28Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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