Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries

Smith, Lee and Shin, Jae Il and Jacob, Louis and Carmichael, Christina and López-Sánchez, Guillermo F. and Oh, Hans and Butler, Laurie T. and Barnett, Yvonne A. and Pizzol, Damiano and Tully, Mark A. and Soysal, Pinar and Veronese, Nicola and Koyanagi, Ai (2021) Sleep problems and mild cognitive impairment among adults aged ≥50 years from low- and middle-income countries. Experimental Gerontology, 154. p. 111513. ISSN 1873-6815

[img] Text
Accepted Version
Restricted to Repository staff only until 10 August 2022.
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (418kB) | Request a copy
[img] Text (Word version)
Accepted Version
Restricted to Repository staff only until 10 August 2022.
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (105kB) | Request a copy
Official URL: https://doi.org/10.1016/j.exger.2021.111513

Abstract

Background- The limited available literature suggests that sleep problems are linked to an increased risk of mild cognitive impairment (MCI). However, this association has been little studied to date in low-income settings. Objective- To investigate the association between sleep problems and MCI in a large sample of adults from six low-and middle-income countries (LMICs). Design- Cross-sectional. Setting- Study on Global Ageing and Adult Health (SAGE). Subjects- 32,715 individuals aged ≥50 years with preservation in functional abilities [age range 50–114 years; 51.7% females]. Methods- MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Sleep problems were assessed by the question “Overall in the last 30 days, how much of a problem did you have with sleeping, such as falling asleep, waking up frequently during the night or waking up too early in the morning?” and categorized as “None”, “Mild”, “Moderate”, “Severe/Extreme”. Multivariable logistic regression analysis and meta-analysis were conducted. Results- Compared to no sleep problems, mild, moderate, and severe/extreme sleep problems were associated with significant 1.40, 1.83, and 2.69 times higher odds for MCI with similar associations being observed between age groups and sex. Severe/extreme sleep problems were positively associated with MCI (i.e., OR > 1) in the six countries studied with the overall estimate being OR = 1.80 (95% CI = 1.50–2.16), and a low level of between-country heterogeneity was observed (I2 = 28.2%). Conclusions- Sleep problems were associated with higher odds for MCI. Interventions to improve sleep quality among middle-aged and older adults in LMICs may be an effective strategy in reducing risk of MCI and dementia.

Item Type: Journal Article
Keywords: Sleep problems, Mild cognitive impairment, LMICs, Dementia, Low- and middle-income countries, Middle-aged adults, Older adults
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 09 Aug 2021 08:41
Last Modified: 24 Sep 2021 14:56
URI: https://arro.anglia.ac.uk/id/eprint/706791

Actions (login required)

Edit Item Edit Item