Hao_et_al_2021.pdf (3.06 MB)
Construction of Novel Nanocomposites (Cu-MOF/GOD@HA) for Chemodynamic Therapy
journal contribution
posted on 2023-07-26, 15:28 authored by Ya-Nan Hao, Cong-Cong Qu, Yang Shu, Jian-Hua Wang, Wei ChenThe emerging chemodynamic therapy (CDT) has received an extensive attention in recent years. However, the efficiency of CDT is influenced due to the limitation of H2O2 in tumor. In this study, we designed and synthesized a novel core-shell nanostructure, Cu-metal organic framework (Cu-MOF)/glucose oxidase (GOD)@hyaluronic acid (HA) (Cu-MOF/GOD@HA) for the purpose of improving CDT efficacy by increasing H2O2 concentration and cancer cell targeting. In this design, Cu-MOF act as a CDT agent and GOD carrier. Cu(II) in Cu-MOF are reduced to Cu(I) by GSH to obtain Cu(I)-MOF while GSH is depleted. The depletion of GSH reinforces the concentration of H2O2 in tumor to improve the efficiency of CDT. The resultant Cu(I)-MOF catalyze H2O2 to generate hydroxyl radicals (·OH) for CDT. GOD can catalyze glucose (Glu) to supply H2O2 for CDT enhancement. HA act as a targeting molecule to improve the targeting ability of Cu-MOF/GOD@HA to the tumor cells. In addition, after loading with GOD and coating with HA, the proportion of Cu(I) in Cu-MOF/GOD@HA is increased compared with the proportion of Cu(I) in Cu-MOF. This phenomenon may shorten the reactive time from Cu-MOF to Cu(I)-MOF. The CDT enhancement as a result of GOD and HA effects in Cu-MOF/GOD@HA was evidenced by in vitro cell and in vivo animal studies.
History
Refereed
- Yes
Volume
11Issue number
7Page range
1843Publication title
NanomaterialsISSN
2079-4991External DOI
Publisher
MDPIFile version
- Published version
Language
- eng
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Legacy posted date
2021-08-02Legacy creation date
2021-08-02Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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