Nutrition and Frailty: Opportunities for Prevention and Treatment

Ni Lochlainn, Mary and Cox, Natalie J. and Wilson, Thomas and Hayhoe, Richard P. G. and Ramsay, Sheena E. and Granic, Antoneta and Isanejad, Masoud and Roberts, Helen C. and Wilson, Daisy and Welch, Carly and Hurst, Christopher and Atkins, Janice L. and Mendonça, Nuno and Horner, Katy and Tuttiett, Esme R. and Morgan, Yvie and Heslop, Phil and Williams, Elizabeth A. and Steves, Claire J. and Greig, Carolyn and Draper, John and Corish, Clare A. and Welch, Ailsa A. and Witham, Miles D. and Sayer, Avan A. and Robinson, Sian (2021) Nutrition and Frailty: Opportunities for Prevention and Treatment. Nutrients, 13 (7). p. 2349. ISSN 2072-6643

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Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is considered a key contributor to its pathophysiology. As nutrition is a modifiable risk factor for frailty, strategies to prevent and treat frailty should consider dietary change. Observational evidence linking nutrition with frailty appears most robust for dietary quality: for example, dietary patterns such as the Mediterranean diet appear to be protective. In addition, research on specific foods, such as a higher consumption of fruit and vegetables and lower consumption of ultra-processed foods are consistent, with healthier profiles linked to lower frailty risk. Few dietary intervention studies have been conducted to date, although a growing number of trials that combine supplementation with exercise training suggest a multi-domain approach may be more effective. This review is based on an interdisciplinary workshop, held in November 2020, and synthesises current understanding of dietary influences on frailty, focusing on opportunities for prevention and treatment. Longer term prospective studies and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression and how dietary change can be used to prevent and/or treat frailty in the future.

Item Type: Journal Article
Keywords: frailty, ageing, inflammation, appetite, microbiome, metabolome
Faculty: Faculty of Health, Education, Medicine & Social Care
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 22 Jul 2021 11:52
Last Modified: 09 Sep 2021 18:50

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