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Ejaculation disorders in male patients with cancer: a systematic review and meta-analysis of prevalence
journal contribution
posted on 2023-09-01, 14:47 authored by Damiano Pizzol, Mike Trott, Igor Grabovac, Lin Yang, Yvonne A. Barnett, Christopher N. Parris, Daragh T. McDermott, Nicola Veronese, Andreas Kronbichler, Ramy A. Ghayda, Pinar Soysal, Louis Jacob, Mark A. Tully, Ai Koyanagi, Christopher Law, Coskun Kaya, Nannan Thirumavalavan, Aram Loeb, Andrea Garolla, Seoyeon Park, Jae Il Shin, Petre Ilie, Lee SmithPurpose:
Ejaculatory dysfunction (EjD) and erectile dysfunction after cancer treatment are clinically important complications, but their exact prevalence by various kinds of cancer site and type of treatment is unknown. The aim of this systematic review and meta-analysis was to examine the available evidence and provide pooled estimates for prevalence of EjD and erectile dysfunction in relation to all cancer sites and identify characteristics associated with EjD in cancer patients.
Materials and Methods:
We performed a systematic review and meta-analysis of cross-sectional and case-control studies. We searched four electronic databases (Medline, CINAHL, PsychInfo and Embase) until 22nd July 2020. All retrospective or prospective studies reporting the prevalence of EjD in male patients with cancer were included in this review. A random effects meta-analysis was conducted calculating prevalence proportions with 95% confidence intervals (CIs). Prevalence proportions were calculated for the incidences of EjD by cancer site and type of treatment.
Results:
A total of 64 studies (a total of 10,057 participants) were included for analysis. The most common cancer sites were bladder, colon, testis and rectum. The prevalence rates of EjD after surgical intervention ranged from 14.5% (95% CI 2.2–56.3%) in colon cancer to 53.0% (23.3–80.7%) in bladder cancer. The prevalence rates of erectile dysfunction ranged from 6.8% (95% CI 0.8–39.1%) in bladder cancer to 68.7% (95% CI 55.2–79.6%) in cancer of the rectum.
Conclusions:
In a large study-level meta-analysis, we looked at a high prevalence of EjD and erectile dysfunction at various cancer sites and across different treatment types. Prospective studies of EjD and erectile dysfunction after various kinds of cancer treatments are warranted.
History
Refereed
- Yes
Volume
206Issue number
6Page range
1361-1372Publication title
Journal of UrologyISSN
0022-5347External DOI
Publisher
American Urological AssociationFile version
- Accepted version
Language
- eng
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Legacy posted date
2021-07-19Legacy creation date
2021-07-19Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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