Hwang, Jimin, Lee, Se Bee, Lee, Seung Won, Lee, Minho, Koyanagi, Ai, Jacob, Louis, Tizaoui, Kalthoum, Yon, Dong Keon, Shin, Jae Il and Smith, Lee (2021) Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines. Journal of Autoimmunity, 122. p. 102681. ISSN 0896-8411
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Abstract
Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination.
Item Type: | Journal Article |
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Keywords: | Vaccine-induced thrombotic thrombocytopenia, Thrombotic thrombocytopenia syndrome, Adenoviral vector vaccine, COVID-19 vaccine, Cerebral venous thrombosis |
Faculty: | COVID-19 Research Collection Faculty of Science & Engineering |
SWORD Depositor: | Symplectic User |
Depositing User: | Symplectic User |
Date Deposited: | 02 Jun 2021 11:05 |
Last Modified: | 15 Jun 2022 01:02 |
URI: | https://arro.anglia.ac.uk/id/eprint/706626 |
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