Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines

Hwang, Jimin and Lee, Se Bee and Lee, Seung Won and Lee, Minho and Koyanagi, Ai and Jacob, Louis and Tizaoui, Kalthoum and Yon, Dong Keon and Shin, Jae Il and Smith, Lee (2021) Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines. Journal of Autoimmunity, 122. p. 102681. ISSN 0896-8411

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Official URL: https://doi.org/10.1016/j.jaut.2021.102681

Abstract

Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination.

Item Type: Journal Article
Keywords: Vaccine-induced thrombotic thrombocytopenia, Thrombotic thrombocytopenia syndrome, Adenoviral vector vaccine, COVID-19 vaccine, Cerebral venous thrombosis
Faculty: COVID-19 Research Collection
Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 02 Jun 2021 11:05
Last Modified: 06 Jan 2022 15:06
URI: https://arro.anglia.ac.uk/id/eprint/706626

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