Hwang, Jimin and Lee, Se Bee and Lee, Seung Won and Lee, Minho and Koyanagi, Ai and Jacob, Louis and Tizaoui, Kalthoum and Yon, Dong Keon and Shin, Jae Il and Smith, Lee (2021) Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines. Journal of Autoimmunity, 122. p. 102681. ISSN 0896-8411
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Accepted Version Restricted to Repository staff only until 15 June 2022. Available under the following license: Creative Commons Attribution Non-commercial No Derivatives. Download (58kB) | Request a copy |
Abstract
Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination.
Item Type: | Journal Article |
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Keywords: | Vaccine-induced thrombotic thrombocytopenia, Thrombotic thrombocytopenia syndrome, Adenoviral vector vaccine, COVID-19 vaccine, Cerebral venous thrombosis |
Faculty: | COVID-19 Research Collection Faculty of Science & Engineering |
SWORD Depositor: | Symplectic User |
Depositing User: | Symplectic User |
Date Deposited: | 02 Jun 2021 11:05 |
Last Modified: | 06 Jan 2022 15:06 |
URI: | https://arro.anglia.ac.uk/id/eprint/706626 |
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