Empagliflozin Use and Fournier’s Gangrene: Case Report and Systematic Literature Review

Antunes, Mario and Cabrera de León, Antonio and Pizzol, Damiano and Hussein Abubacar Seni, Amir and Trott, Mike and Carrie, Anne and Ilie, Petre-Cristian and Veronese, Nicola and Smith, Lee (2021) Empagliflozin Use and Fournier’s Gangrene: Case Report and Systematic Literature Review. Surgeries, 2 (2). pp. 174-179. ISSN 2673-4095

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Official URL: https://doi.org/10.3390/surgeries2020018


Background: Fournier’s gangrene (FG) is a rare necrotising soft tissue infection localised in the genital areas with possible dramatic outcomes. Recently, sodium glucose co-transporter-2 (SGLT2) inhibitors were identified as a risk factor. Methods: We present a case report of a 57-year-old female patient with type 2 diabetes mellitus (T2DM) in treatment with empagliflozin which led to the development of FG. Moreover, we performed a systematic review assessing the association between empagliflozin use and FG. Results: The female patient with 15-years treated diabetes presented a massive FG after 6 months from starting empagliflozin. Over the period of two months, she was successfully treated in a low-income setting. The systematic review included two studies with a total of 9915 participants. Although no participant had FG, there was an increased rate of urinary and genital infection in patients treated with empagliflozin compared to those treated with other antidiabetics or placebo. Conclusions: FG should be considered as a possible complication in patients using SGLT2. Patients should be educated to report early signs of genital infection and healthy behaviours as well as a balanced diet should be promoted to aid in the prevention of FG.

Item Type: Journal Article
Keywords: Empagliflozin, Fournier’s Gangrene, Case report, Systematic review, Sodium-glucose transporter 2 inhibitors, SGLT2-inhibitors, Diabetes
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 10 May 2021 13:32
Last Modified: 09 Sep 2021 18:50
URI: https://arro.anglia.ac.uk/id/eprint/706573

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