Roles of microRNAs in inflammatory bowel disease

Jung, Hyun Taek and Kim, Jae Seok and Lee, Keum Hwa and Tizaoui, Kalthoum and Terrazzino, Salvatore and Cargnin, Sarah and Smith, Lee and Koyanagi, Ai and Jacob, Louis and Li, Han and Hong, Sung Hwi and Yon, Dong Keon and Lee, Seung Won and Kim, Min Seo and Wasuwanich, Paul and Shin, Jae Il and Kronbichler, Andreas (2021) Roles of microRNAs in inflammatory bowel disease. International Journal of Biological Sciences, 17 (8). pp. 2112-2123. ISSN 1449-2288

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Official URL: http://dx.doi.org/10.7150/ijbs.59904

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. IBD is associated with various gastrointestinal symptoms, and thus, affects the quality of life of patients. Currently, the pathogenesis of IBD is poorly understood. Although intestinal bacteria and host immune response are thought to be major factors in its pathogenesis, a sufficient explanation of their role in its pathophysiologic mechanism has not been presented. MicroRNAs (miRNAs), which are small RNA molecules that regulate gene expression, have gained attention as they are known to participate in the molecular interactions of IBD. Recent studies have confirmed the important role of miRNAs in targeting certain molecules in signaling pathways that regulate the homeostasis of the intestinal barrier, inflammatory reactions, and autophagy of the intestinal epithelium. Several studies have identified the specific miRNAs associated with IBD from colon tissues or serum samples of IBD patients and have attempted to use them as useful diagnostic biomarkers. Furthermore, some studies have attempted to treat IBD through intracolonic administration of specific miRNAs in the form of nanoparticle. This review summarizes the latest findings on the role of miRNAs in the pathogenesis, diagnosis, and treatment of IBD.

Item Type: Journal Article
Keywords: inflammatory bowel diseases, crohn’s disease, ulcerative colitis, microRNAs
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 05 May 2021 10:08
Last Modified: 09 Sep 2021 18:50
URI: https://arro.anglia.ac.uk/id/eprint/706550

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