Neurological diseases and COVID-19: prospective analyses using the UK Biobank

Veronese, Nicola and Smith, Lee and Barbagallo, Mario and Giannelli, Gianluigi and Caruso, Maria and Cisternino, Anna and Notarnicola, Maria and Cao, Chao and Waldhoer, Thomas and Yang, Lin (2021) Neurological diseases and COVID-19: prospective analyses using the UK Biobank. Acta Neurologica Belgica, 121. pp. 1295-1303. ISSN 2240-2993

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Abstract

COVID-19 (Coronavirus disease-19) may present with neurological signs, but whether people already affected by neurological conditions are at a higher risk of contracting COVID-19 is still not known. We, therefore, aimed to investigate the association of previously diagnosed neurological conditions with COVID-19. 502,536 community-dwelling UK Biobank participants (54.4% male, mean age 56.6 ± 10.3 years) were included. Among these, 57,463 participants had a diagnosis of neurological conditions (11.43%) and a total of 1326 COVID-19-positive cases were identified (0.26%). Neurological conditions were identified through medical history and linkage to data on hospital admissions (ICD-10 code G00-G99). COVID-19 presence was diagnosed using the data provided by Public Health England. The association of previous diagnosis of neurological conditions with COVID-19 was evaluated through logistic regressions, adjusted for potential confounders, reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Nerve, nerve root and plexus disorders (G50-G59) were the most common conditions identified. The presence of COVID-19 was almost doubled in neurological conditions compared to the general population (0.45 vs. 0.24%, p < 0.0001). Previously diagnosed neurological conditions were associated with 60% higher odds of COVID-19 positive in the multivariable-adjusted model (OR = 1.6, 95% CI 1.4-1.8). Other degenerative diseases of the nervous system, extrapyramidal and movement disorders, polyneuropathies and other disorders of the peripheral nervous system, cerebral palsy and other paralytic syndromes were significantly associated with a higher odds of COVID-19. The presence of neurological conditions was associated with a significantly higher likelihood of COVID-19 compared to the general population.

Item Type:	Journal Article
Keywords:	COVID-19, Neurological Disease, UK Biobank
Faculty:	COVID-19 Research Collection Faculty of Science & Engineering
SWORD Depositor:	Symplectic User
Depositing User:	Symplectic User
Date Deposited:	26 Apr 2021 10:45
Last Modified:	24 Sep 2021 11:03
URI:	https://arro.anglia.ac.uk/id/eprint/706521

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