Effectiveness of Adjunctive Analgesics in Head and Neck Cancer Patients Receiving Curative (Chemo-) Radiotherapy: A Systematic Review

Lefebvre, Tessa and Tack, Laura and Lycke, Michelle and Duprez, Fréderic and Goethals, Laurence and Rottey, Sylvie and Cool, Lieselot and Van Eygen, Koen and Stubbs, Brendon and Schofield, Patricia and Pottel, Hans and Boterberg, Tom and Debruyne, Philip R. (2021) Effectiveness of Adjunctive Analgesics in Head and Neck Cancer Patients Receiving Curative (Chemo-) Radiotherapy: A Systematic Review. Pain Medicine, 22 (1). pp. 152-164. ISSN 1526-4637

Full text not available from this repository.
Official URL: https://doi.org/10.1093/pm/pnaa044

Abstract

Objective: Our aim was to give an overview of the effectiveness of adjunctive analgesics in head and neck cancer (HNC) patients receiving (chemo-) radiotherapy. Design: Systematic review. Interventions: This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched for studies concerning “head neck cancer,” “adjunctive analgesics,” “pain,” and “radiotherapy.” Outcome Measures: Pain outcome, adverse events, and toxicity and other reported outcomes, for example, mucositis, quality of life, depression, etc. Results: Nine studies were included in our synthesis. Most studies were of low quality and had a high risk of bias on several domains of the Cochrane Collaboration tool. Only two studies comprised high-quality randomized controlled trials in which pregabalin and a doxepin rinse showed their effectiveness for the treatment of neuropathic pain and pain from oral mucositis, respectively, in HNC patients receiving (chemo-) radiotherapy. Conclusions: More high-quality trials are necessary to provide clear evidence on the effectiveness of adjunctive analgesics in the treatment of HNC (chemo-) radiation-induced pain.

Item Type: Journal Article
Keywords: Adjunctive Analgesics, Head and Neck Cancer, (Chemo-) Radiotherapy
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Lisa Blanshard
Date Deposited: 22 Mar 2021 12:49
Last Modified: 09 Sep 2021 16:04
URI: https://arro.anglia.ac.uk/id/eprint/706436

Actions (login required)

Edit Item Edit Item