Omega-3 fatty acids supplementation on major cardiovascular outcomes: an umbrella review of meta-analyses of observational studies and randomized controlled trials

Choi, Hyeok and Kim, Jong Yeob and Lee, Keum Hwa and Kim, Jae Seok and Lee, Jun Young and Choi, Eun Kyoung and Seong, Hyo Jin and Kim, Gaeun and Park, Hyunbong and Jung, Eunyoung and Hong, Sung Hwi and Kronbichler, Adreas and Eisenhut, Michael and Koyanagi, Ai and Jacob, Louis and Yon, Dong Keon and Lee, Seung Won and Kim, Min Seo and Kostev, Kral and Shin, Jae Il and Yang, Jae Won and Smith, Lee (2021) Omega-3 fatty acids supplementation on major cardiovascular outcomes: an umbrella review of meta-analyses of observational studies and randomized controlled trials. European Review for Medical and Pharmacological Sciences, 25 (4). pp. 2079-2092. ISSN 2284-0729

[img]
Preview
Text
Published Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (739kB) | Preview
[img] Text
Accepted Version
Restricted to Repository staff only
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (731kB) | Request a copy
Official URL: http://dx.doi.org/10.26355/eurrev_202102_25113

Abstract

OBJECTIVE: Omega-3 fatty acids are commonly used as a lipid-lowering agent or dietary supplement for the purpose of prevention of cardiovascular diseases. However, even large-scale clinical trials have not shown significant results demonstrating clear clinical benefits in cardiovascular diseases. Thus, this umbrella review aims to summarize and evaluate the evidence of clinical effects of omega-3 fatty acids supplementation on cardiovascular outcomes through comprehensive analyses of previous randomized controlled trials (RCTs) or observational cohort studies. MATERIALS AND METHODS: We conducted relevant publication search in PubMed, Embase, and Cochrane Database of Systematic Reviews. We retrieved and analyzed 3,298 articles published until August 28th, 2019. RESULTS: We identified 29 relevant articles and analyzed 83 meta-analyses of RCTs or cohort studies therefrom. As a result, we identified 12 cardiovascular outcomes that are related to omega-3 fatty acids supplementation. Among them, total mortality from major cardiovascular causes (RR 0.92, 95% CI 0.86 to 0.98) had significant inverse associations, and moreover, statistical significances were maintained even in subgroup analysis of large-scale RCTs including more than 1,000 patients (RR 0.94, 95% CI 0.88 to 0.99). CONCLUSIONS: Our umbrella review study shows that omega-3 fatty acids supplementation have a clinical benefit in reducing mortality from cardiovascular causes. However, many studies still have shown conflicting results, and therefore, further studies will be needed to verify the clinical benefit of omega-3 supplementation.

Item Type: Journal Article
Keywords: Omega-3 fatty acids, Supplementation, Cardiovascular outcome, Mortality, Systematic review, Meta-analysis
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 23 Feb 2021 11:29
Last Modified: 09 Sep 2021 18:51
URI: https://arro.anglia.ac.uk/id/eprint/706351

Actions (login required)

Edit Item Edit Item