Pierscionek_et_al_2015.pdf (6.11 MB)
The eye lens: age-related trends and individual variations in refractive index and shape parameters
journal contribution
posted on 2023-07-26, 15:16 authored by Barbara K. Pierscionek, Mehdi Bahrami, Masato Hoshino, Kentaro Uesugi, Justyn Regini, Naoto YagiThe eye lens grows throughout life by cell accrual on its surface and can change shape to adjust the focussing power of the eye. Varying concentrations of proteins in successive cell layers create a refractive index gradient. The continued growth of the lens and age-related changes in proteins render it less able to alter shape with loss of capacity by the end of the sixth decade of life. Growth and protein ageing alter the refractive index but as accurate measurement of this parameter is difficult, the nature of such alterations remains uncertain. The most accurate method to date for measuring refractive index in intact lenses has been developed at the SPring-8 synchrotron. The technique, based on Talbot interferometry, has an X-ray source and was used to measure refractive index in sixty-six human lenses, aged from 16 to 91 years. Height and width were measured for forty-five lenses. Refractive index contours show decentration in some older lenses but individual variations mask age-related trends. Refractive index profiles along the optic axis have relatively flat central sections with distinct micro-fluctuations and a steep gradient in the cortex but do not exhibit an age-related trend. The refractive index profiles in the equatorial aspect show statistical significance with age, particularly for lenses below the age of sixty that had capacity to alter shape in vivo. The maximum refractive index in the lens centre decreases slightly with age with considerable scatter in the data and there are age-related variations in sagittal thickness and equatorial height.
History
Refereed
- Yes
Volume
6Issue number
31Page range
30532-30544Publication title
OncotargetISSN
1949-2553External DOI
Publisher
Impact JournalsFile version
- Published version
Language
- eng
Official URL
Legacy posted date
2021-02-22Legacy creation date
2021-02-22Legacy Faculty/School/Department
ARCHIVED Faculty of Health, Social Care & Education (until September 2018)Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC