The suprachoroidal pathway: a new drug delivery route to the back of the eye

Rai, Uma Do J. P. and Young, Simon A. and Thrimawithana, Thilini R. and Abdelkader, Hamdy and Alani, Adam W. G. and Pierscionek, Barbara K. and Alany, Raid G. (2015) The suprachoroidal pathway: a new drug delivery route to the back of the eye. Drug Discovery Today, 20 (4). pp. 491-495. ISSN 1359-6446

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Official URL: https://doi.org/10.1016/j.drudis.2014.10.010

Abstract

The development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.

Item Type: Journal Article
Faculty: ARCHIVED Faculty of Health, Social Care & Education (until September 2018)
Depositing User: Lisa Blanshard
Date Deposited: 22 Feb 2021 11:02
Last Modified: 22 Feb 2021 11:02
URI: https://arro.anglia.ac.uk/id/eprint/706344

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