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The suprachoroidal pathway: a new drug delivery route to the back of the eye
journal contribution
posted on 2023-07-26, 15:16 authored by Uma Do J. P. Rai, Simon A. Young, Thilini R. Thrimawithana, Hamdy Abdelkader, Adam W. G. Alani, Barbara K. Pierscionek, Raid G. AlanyThe development of safe and convenient drug delivery strategies for treatment of posterior segment eye diseases is challenging. Although intravitreal injection has wide acceptance amongst clinicians, its use is associated with serious side-effects. Recently, the suprachoroidal space (SCS) has attracted the attention of ophthalmologists and pharmaceutical formulators as a potential site for drug administration and delivery to the posterior segment of the eye. This review highlights the major constraints of drug delivery to the posterior eye segment, key anatomical and physiological features of the SCS and drug delivery applications of this route with emphasis on microneedles along with future perspectives.
History
Refereed
- Yes
Volume
20Issue number
4Page range
491-495Publication title
Drug Discovery TodayISSN
1359-6446External DOI
Publisher
ElsevierLanguage
- other
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2021-02-22Legacy Faculty/School/Department
ARCHIVED Faculty of Health, Social Care & Education (until September 2018)Usage metrics
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