Grzybowski_et_al_2018.pdf (501.15 kB)
Maximum human objectively measured pharmacologically stimulated accommodative amplitude
journal contribution
posted on 2023-07-26, 15:14 authored by Andrzej Grzybowski, Ronald A. Schachar, Magdalena Gaca-Wysocka, Ira H. Schachar, Barbara K. PierscionekPurpose: To measure the maximum, objectively measured, accommodative amplitude, produced by pharmacologic stimulation.
Methods: Thirty-seven healthy subjects were enrolled, with a mean age of 20.2±1.1 years, corrected visual acuity of 20/20, and mean spherical equivalent refraction (SER) =–0.83±1.60 diopters. For each subject, the right pupil was dilated with phenylephrine 10%. After 30 minutes, the pupil was measured, the left eye was patched, and the right eye was autorefracted. Pilocarpine 4% was then instilled in the right eye, followed by phenylephrine. At 45 minutes after the pilocarpine, autorefraction and pupil size were again measured.
Results: Mean pupil size pre- and postpilocarpine was 8.0±0.8 mm and 4.4±1.9 mm, respectively. Pre- and postpilocarpine, the mean SER was –0.83±1.60 and –10.55±4.26 diopters, respectively. The mean pilocarpine-induced accommodative amplitude was 9.73±3.64 diopters. Five subjects had accommodative amplitudes ≥14.00 diopters. Accommodative amplitude was not significantly related to baseline SER (p-value =0.24), pre- or postpilocarpine pupil size (p-values =0.13 and 0.74), or change in pupil size (p-value =0.37). Iris color did not statistically significantly affect accommodative amplitude (p-value =0.83).
Conclusion: Following topically applied pilocarpine, the induced objectively measured accommodation in the young eye is greater than or equal to the reported subjectively measured voluntary maximum accommodative amplitude.
History
Refereed
- Yes
Volume
12Page range
201-205Publication title
Clinical OphthalmologyISSN
1177-5483External DOI
Publisher
Dove Medical PressFile version
- Published version
Language
- eng
Official URL
Legacy posted date
2021-02-18Legacy creation date
2021-02-18Legacy Faculty/School/Department
ARCHIVED Faculty of Health, Social Care & Education (until September 2018)Usage metrics
Categories
No categories selectedLicence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC