Body mass index and mortality in patients with cardiovascular disease: An umbrella review of meta-analyses

Ghayda, Ramy A. and Park, David D. and Lee, Jun Young and Kim, Jong Yeob and Lee, Keum Hwa and Hong, Sung Hwi and Yang, Jae Won and Kim, Jae Seok and Jeong, Gwang Hun and Kronbichler, Andreas and Koyanagi, Ai and Jacob, Louis and Oh, Hans and Li, Han and Yang, Jee Myung and Kim, Min Seo and Lee, Seung Won and Yon, Dong Keon and Shin, Jae Il and Smith, Lee (2021) Body mass index and mortality in patients with cardiovascular disease: An umbrella review of meta-analyses. European Review for Medical and Pharmacological Sciences, 25 (1). pp. 273-286. ISSN 2284-0729

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Abstract

OBJECTIVE: Although many previous meta-analyses of epidemiological studies have demonstrated a relationship between body mass index (BMI) and mortality, inconsistent findings among cardiovascular disease patients have been observed. Thus, we performed an umbrella review to understand the strength of evidence and validity of claimed associations between BMI and mortality in patients with cardiovascular diseases. MATERIALS AND METHODS: We comprehensively re-analyzed the data of meta-analyses of observational studies and randomized controlled trials on associations between BMI and mortality among patients with cardiovascular diseases. We also assessed the strength of evidence of the re-analyzed outcomes, which were determined from the criteria including statistical significance of the p-value of random-effects, as well as fixed-effects meta-analyses, small-study effects, between-study heterogeneity, and a 95% prediction interval. RESULTS: We ran comprehensive re-analysis of the data from the 21 selected studies, which contained a total of 108 meta-analyses; 23 were graded as convincing evidence and 12 were suggestive, 42 were weak, and 23 were non-significant. CONCLUSIONS: Underweight increased mortality in acute coronary syndrome (ACS), heart failure, and after therapeutic intervention for patients with cardiovascular diseases. Overweight, on the other hand decreased mortality in patient’s ACS, atrial fibrillation, and heart failure with convincing evidence.

Item Type:	Journal Article
Keywords:	BMI, Cardiovascular Disease, Mortality, Umbrella Review, Meta-analysis, Obesity
Faculty:	Faculty of Science & Engineering
SWORD Depositor:	Symplectic User
Depositing User:	Symplectic User
Date Deposited:	13 Nov 2020 11:58
Last Modified:	16 Feb 2021 15:48
URI:	https://arro.anglia.ac.uk/id/eprint/706048

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