posted on 2023-08-30, 17:53authored byRamy A. Ghayda, David D. Park, Jun Young Lee, Jong Yeob Kim, Keum Hwa Lee, Sung Hwi Hong, Jae Won Yang, Jae Seok Kim, Gwang Hun Jeong, Andreas Kronbichler, Ai Koyanagi, Louis Jacob, Hans Oh, Han Li, Jee Myung Yang, Min Seo Kim, Seung Won Lee, Dong Keon Yon, Jae Il Shin, Lee Smith
OBJECTIVE: Although many previous meta-analyses of epidemiological studies have demonstrated a relationship between body mass index (BMI) and mortality, inconsistent findings among cardiovascular disease patients have been observed. Thus, we performed an umbrella review to understand the strength of evidence and validity of claimed associations between BMI and mortality in patients with cardiovascular diseases.
MATERIALS AND METHODS: We comprehensively re-analyzed the data of meta-analyses of observational studies and randomized controlled trials on associations between BMI and mortality among patients with cardiovascular diseases. We also assessed the strength of evidence of the re-analyzed outcomes, which were determined from the criteria including statistical significance of the p-value of random-effects, as well as fixed-effects meta-analyses, small-study effects, between-study heterogeneity, and a 95% prediction interval.
RESULTS: We ran comprehensive re-analysis of the data from the 21 selected studies, which contained a total of 108 meta-analyses; 23 were graded as convincing evidence and 12 were suggestive, 42 were weak, and 23 were non-significant.
CONCLUSIONS: Underweight increased mortality in acute coronary syndrome (ACS), heart failure, and after therapeutic intervention for patients with cardiovascular diseases. Overweight, on the other hand decreased mortality in patient’s ACS, atrial fibrillation, and heart failure with convincing evidence.
History
Refereed
Yes
Volume
25
Issue number
1
Page range
273-286
Publication title
European Review for Medical and Pharmacological Sciences