Sze_et_al_2021.pdf (1.94 MB)
Effect of frailty on treatment, hospitalisation and death in patients with chronic heart failure
journal contribution
posted on 2023-07-26, 15:10 authored by Shirley Sze, Pierpaolo Pellicori, Jufen Zhang, Joan Weston, I. B. Squire, Andrew L. ClarkBackground:
Frailty is common in patients with chronic heart failure (CHF) and is associated with poor outcomes. The natural history of frail patients with CHF is unknown.
Methods:
Frailty was assessed using the clinical frailty scale (CFS) in 467 consecutive patients with CHF (67% male, median age 76 years, median NT-proBNP 1156 ng/L) attending a routine follow-up visit. Those with CFS > 4 were classified as frail. We investigated the relation between frailty and treatments, hospitalisation and death in patients with CHF.
Results:
206 patients (44%) were frail. Of 291 patients with HF with reduced ejection fraction (HeFREF), those who were frail (N = 117; 40%) were less likely to receive optimal treatment, with many not receiving a renin–angiotensin–aldosterone system inhibitor (frail: 25% vs. non-frail: 4%), a beta-blocker (16% vs. 8%) or a mineralocorticoid receptor antagonist (50% vs 41%). By 1 year, there were 56 deaths and 322 hospitalisations, of which 25 (45%) and 198 (61%), respectively, were due to non-cardiovascular (non-CV) causes. Most deaths (N = 46, 82%) and hospitalisations (N = 215, 67%) occurred in frail patients. Amongst frail patients, 43% of deaths and 64% of hospitalisations were for non-CV causes; 58% of cardiovascular (CV) deaths were due to advancing HF. Among non-frail patients, 50% of deaths and 57% of hospitalisations were for non-CV causes; all CV deaths were due to advancing HF.
Conclusion:
Frailty in patients with HeFREF is associated with sub-optimal medical treatment. Frail patients are more likely to die or be admitted to hospital, but whether frail or not, many events are non-CV.
History
Refereed
- Yes
Volume
110Page range
1249-1258Publication title
Clinical Research in CardiologyISSN
1861-0692External DOI
Publisher
SpringerFile version
- Published version
Language
- eng
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2020-11-10Legacy creation date
2020-11-10Legacy Faculty/School/Department
Faculty of Health, Education, Medicine & Social CareUsage metrics
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