Adherence to a healthy lifestyle and Multiple Sclerosis: a case-control study from the UK Biobank

Veronese, Nicola and Yang, Lin and Piccio, Laura and Smith, Lee and Firth, Joseph and Marx, Wolfgang and Giannelli, Gianluigi and Caruso, Maria G. and Cisternino, Anna and Notarnicola, Maria and Donghia, Rossella and Barbagallo, Mario and Fontana, Luigi (2020) Adherence to a healthy lifestyle and Multiple Sclerosis: a case-control study from the UK Biobank. Nutritional Neuroscience. ISSN 1476-8305

[img] Text
Accepted Version
Restricted to Repository staff only until 9 December 2021.
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (112kB) | Request a copy
Official URL:


Background: Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored. Objective: To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS). Methods: By using a case–control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs). Results: 728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0–1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15–0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS. Conclusion: Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.

Item Type: Journal Article
Keywords: Multiple Sclerosis, UK Biobank, healthy lifestyle, healthy diet, smoke, obesity
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 02 Nov 2020 10:48
Last Modified: 09 Sep 2021 18:52

Actions (login required)

Edit Item Edit Item