Veronese_et_al_2020.docx (109.51 kB)
Adherence to a healthy lifestyle and Multiple Sclerosis: a case-control study from the UK Biobank
journal contribution
posted on 2023-08-30, 17:50 authored by Nicola Veronese, Lin Yang, Laura Piccio, Lee Smith, Joseph Firth, Wolfgang Marx, Gianluigi Giannelli, Maria G. Caruso, Anna Cisternino, Maria Notarnicola, Rossella Donghia, Mario Barbagallo, Luigi FontanaBackground:
Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.
Objective:
To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).
Methods:
By using a case–control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).
Results:
728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0–1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15–0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.
Conclusion:
Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.
History
Refereed
- Yes
Volume
25Issue number
6Page range
1231-1239Publication title
Nutritional NeuroscienceISSN
1476-8305External DOI
Publisher
Taylor & FrancisFile version
- Accepted version
Language
- eng
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Legacy posted date
2020-11-02Legacy creation date
2020-11-02Legacy Faculty/School/Department
Faculty of Science & EngineeringUsage metrics
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