Effect of an acute blood donation on oxygen uptake kinetics in moderate and heavy domains over a period of 96 hours

Johnson, Diane M. and Roberts, Justin D. and Gordon, Dan (2020) Effect of an acute blood donation on oxygen uptake kinetics in moderate and heavy domains over a period of 96 hours. Transfusion, 60 (12). pp. 2896-2906. ISSN 1537-2995

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Official URL: http://dx.doi.org/10.1111/trf.16058

Abstract

BACKGROUND: Studies determining the effects of blood donation (BD) on oxygen uptake kinetics are limited. This study aims to ascertain the effects of BD (~470 mL) over a period of 96 hours on oxygen uptake kinetics in moderate and heavy exercise domains. STUDY DESIGN AND METHODS: Twelve participants (nine males and three females; 31.1 ± 11.7 years, mass 79.9 ± 12.8 kg, height 175.5 ± 7.5 cm) completed four consecutive days (24-96 hours) of moderate and heavy V˙O2 on-kinetics trials pre BD and post BD. Visit one (0 hour), pre BD established hematological levels, V˙O2max and Gas Exchange Threshold (GET). Subsequent visits comprised two 6-minute moderate (∆ 50% rest-GET) and 1 heavy (∆ 20% GET-V˙O2max ) trial. Post BD 0 hour the participants donated blood post hematological testing only. RESULTS: Despite non-significances for V˙O2 amplitude, time constant-2 (tau2 ) for V˙O2 showed significant decreases at 24 and 48 hours, and tau3 showed significant increases at 72 and 96 hours pre to post BD (P < .05). Hemoglobin (Hb) values reduced (P < .05) pre (14.48 ± 0.16 g·dL-1 ) to post BD (13.47 ± 0.66 g·dL- 1). Hb significantly decreased at 24, 48, 72, and 96 hours compared to 0 hour post BD (P < .05). CONCLUSION: BD has no effect on V˙O2 amplitude, but time-based components show sensitivity to reduced circulating O2 ; with a decreased PO2 a slower O2 exchange across the blood myocyte barrier could result in altering O2 kinetics.

Item Type: Journal Article
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 22 Sep 2020 14:13
Last Modified: 22 Jan 2021 11:17
URI: https://arro.anglia.ac.uk/id/eprint/705905

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