Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis

Lee, Jinhee and Son, Min Ji and Son, Chei Yun and Jeong, Gwang Hun and Lee, Keum Hwa and Lee, Kwang Seob and Ko, Younhee and Kim, Jong Yeob and Lee, Jun Young and Radua, Joaquim and Eisenhut, Michael and Gressier, Florence and Koyanagi, Ai and Stubbs, Brendon and Solmi, Marco and Rais, Theodor B. and Kronbichler, Andreas and Dragioti, Elena and Vasconcelos, Daniel F. P. and da Silva, Felipe R. P. and Tizaoui, Kalthoum and Brunoni, Andre R. and Carvalho, Andre F. and Cargnin, Sarah and Terrazzino, Salvatore and Stickley, Andrew and Smith, Lee and Thompson, Trevor and Shin, Jae Il and Fusar-Poli, Paolo (2020) Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis. Brain Sciences, 10 (10). p. 692. ISSN 2076-3425

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Official URL: https://doi.org/10.3390/brainsci10100692

Abstract

This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.

Item Type: Journal Article
Keywords: autism spectrum disorder, Genome-Wide Association Studies (GWAS), Meta-analysis, Review, Bayesian false-discovery probability (BFDP), false positive report probability (FPRP)
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 14 Sep 2020 11:42
Last Modified: 01 Oct 2020 12:34
URI: https://arro.anglia.ac.uk/id/eprint/705871

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