Heat acclimation improves sweat gland function and lowers sweat sodium concentration in an adult with cystic fibrosis

Willmott, Ashley G. B. and Holliss, Robert and Saynor, Zoe and Corbett, Jo and Causer, Adam J. and Maxwell, Neil S. (2021) Heat acclimation improves sweat gland function and lowers sweat sodium concentration in an adult with cystic fibrosis. Journal of Cystic Fibrosis, 20 (3). pp. 485-488. ISSN 1569-1993

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Official URL: http://dx.doi.org/10.1016/j.jcf.2020.07.013

Abstract

We present novel data concerning the time-course of adaptations and potential benefits of heat acclimation for people with cystic fibrosis (pwCF), who are at greater risk of exertional heat illness. A 25-year-old male (genotype: delta-F508 and RH117, forced expiratory volume in 1-second: 77% predicted and baseline sweat [Na+]: 70 mmol·L − 1), who had previously experienced muscle cramping during exercise in ambient heat, underwent 10-sessions of heat acclimation (90-min at 40°C and in 40% relative humidity). Adaptations included; lower resting core temperature (-0.40°C) and heart rate (-6 beats·min−1), plasma volume expansion (+6.0%) and, importantly, increased sweat loss (+370 mL) and sweat gland activity (+12 glands·cm2) with decreased sweat [Na+] (-18 mmol·L − 1). Adaptations were maintained for at least 7-days, with no evidence of cramping during follow-up exercise-heat stress testing. These data suggest pwCF may benefit from heat acclimation to induce sudomotor function improvements, particularly reductions in sweat [Na+], however, further research is required.

Item Type: Journal Article
Keywords: Heat acclimation, Cystic fibrosis, Sweat sodium concentration, Adaptation, Heat stress
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 20 Aug 2020 10:21
Last Modified: 23 Nov 2021 17:31
URI: https://arro.anglia.ac.uk/id/eprint/705773

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