Sarcopenia in autoimmune and rheumatic diseases: a comprehensive review

An, Hyo Jin and Tizaoui, Kalthoum and Terrazzino, Salvatore and Cargnin, Sarah and Lee, Keum Hwa and Nam, Seoung Wan and Kim, Jae Seok and Yang, Jae Won and Lee, Jun Young and Smith, Lee and Koyanagi, Ai and Jacob, Louis and Li, Han and Shin, Jae Il and Kronbichler, Andreas (2020) Sarcopenia in autoimmune and rheumatic diseases: a comprehensive review. International Journal of Molecular Sciences, 21. p. 5678. ISSN 1422-0067

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Sarcopenia refers to a decrease in skeletal muscle mass and function. Because sarcopenia affects mortality, and causes significant disability, the clinical importance of sarcopenia is emerging. At first, sarcopenia was recognized as an age-related disease but, recently, it has been reported to be prevalent also in younger patients with autoimmune diseases. Specifically, the association of sarcopenia and autoimmune diseases such as rheumatoid arthritis has been studied in detail. Although the pathogenesis of sarcopenia in autoimmune diseases has not been elucidated, chronic inflammation is believed to contribute to sarcopenia, and moreover the pathogenesis seems to be different depending on the respective underlying disease. The definition of sarcopenia differs among studies, which limits direct comparisons. Therefore, in this review, we cover various definitions of sarcopenia used in previous studies and highlight the prevalence of sarcopenia in diverse autoimmune diseases including rheumatoid arthritis, spondyloarthritis, systemic sclerosis, inflammatory bowel disease, and autoimmune diabetes. In addition, we cover the pathogenesis and treatment of sarcopenia in autoimmune and rheumatic diseases. This review provides a comprehensive understanding of sarcopenia in various autoimmune diseases and highlights the need for a consistent definition of sarcopenia.

Item Type: Journal Article
Keywords: Rheumatic Disease, Sarcopenia, Systematic Review, Autoimmune disease, Rheumatoid arthritis, Inflammatory bowel disease, Type 1 diabetes
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 04 Aug 2020 09:09
Last Modified: 25 Jan 2022 09:19

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