European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction

Weyne, Emmanuel and Ilg, Marcus M. and Cakir, Onur Omer and Muneer, Asif and Roussel, Delphine Behr and Albersen, Maarten and Angulo, Javier and Corona, Giovanni and Bettocchi, Carlo and Reisman, Yacov and Castiglione, Fabio (2020) European Society for Sexual Medicine Consensus Statement on the Use of the Cavernous Nerve Injury Rodent Model to Study Postradical Prostatectomy Erectile Dysfunction. Sexual Medicine. ISSN 2050-1161

[img]
Preview
Text
Accepted Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (552kB) | Preview
Official URL: https://doi.org/10.1016/j.esxm.2020.06.007

Abstract

Introduction: Rodent animal models are currently the most used in vivo model in translational studies looking into the pathophysiology of erectile dysfunction after nerve-sparing radical prostatectomy. Aim: This European Society for Sexual Medicine (ESSM) statement aims to guide scientists toward utilization of the rodent model in an appropriate, timely, and proficient fashion. Methods: MEDLINE and EMBASE databases were searched for basic science studies, using a rodent animal model, looking into the consequence of pelvic nerve injury on erectile function. Main outcome measures: The authors present a consensus on how to best perform experiments with this rodent model, the details of the technique, and highlight possible pitfalls. Results: Owing to the specific issue—basic science—Oxford 2011 Levels of Evidence criteria cannot be applied. However, ESSM statements on this topic will be provided in which we summarize the ESSM position on various aspects of the model such as the use of the Animal Research Reporting In Vivo Experiments guideline and the of common range parameter for nerve stimulation. We also highlighted the translational limits of the model. Conclusion: The following statements were formulated as a suggestive guidance for scientists using the cavernous nerve injury model. With this, we hope to standardize and further improve the quality of research in this field. It must be noted that this model has its limitations.

Item Type: Journal Article
Keywords: animal model, erectile dysfunction, radical prostatectomy, cavernous nerve
Faculty: Faculty of Health, Education, Medicine & Social Care
Depositing User: Ian Walker
Date Deposited: 21 Jul 2020 13:01
Last Modified: 03 Sep 2020 15:39
URI: http://arro.anglia.ac.uk/id/eprint/705707

Actions (login required)

Edit Item Edit Item