Antidepressants during and after Menopausal Transition: A Systematic Review and Meta-Analysis

Wu, Ching-Kuan and Tseng, Ping-Tao and Wu, Ming-Kung and Li, Dian-Jeng and Chen, Tien-Yu and Kuo, Fu-Chen and Stubbs, Brendon and Carvalho, Andre F. and Chen, Yen-Wen and Lin, Pao-Yen and Cheng, Yu-Shian and Sun, Cheuk-Kwan (2020) Antidepressants during and after Menopausal Transition: A Systematic Review and Meta-Analysis. Scientific Reports, 10 (1). p. 8026. ISSN 2045-2322

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To assess the therapeutic benefits of antidepressants in depressive women during and after menopausal transition, PubMed, Cochrane Library, EMBASE and Science Direct were systematically searched from inception to February 1, 2020 for randomized controlled trials examining antidepressants compared to placebo. Primary outcome was change in depressive symptom severity, while secondary outcomes were rates of response/remission rates and dropout/discontinuation due to adverse events. Seven trials involving 1,676 participants (mean age = 52.6 years) showed significant improvement in depressive symptoms (k = 7, Hedges’ g = 0.44, 95% confidence interval (CI) = 0.32 to 0.57, p < 0.001) relative to that in controls. Furthermore, response (k = 3, odds ratio (OR) = 2.53, 95% CI = 1.24 to 5.15, p = 0.01) and remission (k = 3, OR = 1.84, 95% CI = 1.32 to 2.57, p < 0.001) rates were significantly higher in antidepressant-treated groups compared to those with controls. Although dropout rates did not differ between antidepressant and control groups (k = 6, OR = 0.93, 95% CI = 0.70 to 1.26, p = 0.68), the rate of discontinuation due to adverse events was significantly higher in antidepressant-treated groups (k = 6, OR = 0.55, 95% CI = 0.35 to 0.86, p = 0.01). Subgroup analysis indicated that antidepressants were also efficacious for depressive symptoms in those without diagnosis of MDD. The results demonstrated that antidepressants were efficacious for women with depressive syndromes during and after menopausal transition but associated with a higher risk of discontinuation due to adverse events.

Item Type: Journal Article
Faculty: Faculty of Health, Education, Medicine & Social Care
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 03 Jun 2020 15:47
Last Modified: 09 Sep 2021 18:53

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