Evidence-Based Umbrella Review of 162 Peripheral Biomarkers for Major Mental Disorders

Carvalho, Andre F. and Solmi, Marco and Sanches, Marcos and Machado, Myrela O. and Stubbs, Brendon and Ajnakina, Olesya and Sherman, Chelsea and Sun, Yue Ran and Liu, Celina S. and Brunoni, Andre R. and Pigato, Giorgio and Fernandes, Brisa S. and Bortolato, Beatrice and Husain, Muhammad I. and Dragioti, Elena and Firth, Joseph and Cosco, Theodore D. and Maes, Michael and Berk, Michael and Lanctôt, Krista L. and Vieta, Eduard and Pizzagalli, Diego A. and Smith, Lee and Fusar-Poli, Paolo and Kurdyak, Paul A. and Fornaro, Michele and Rehm, Jürgen and Herrmann, Nathan (2020) Evidence-Based Umbrella Review of 162 Peripheral Biomarkers for Major Mental Disorders. Translational Psychiatry, 10. p. 152. ISSN 2158-3188

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Official URL: https://doi.org/10.1038/s41398-020-0835-5


The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with conflicting results. An umbrella review of meta-analyses of non-genetic peripheral biomarkers for Alzheimer’s disease, autism spectrum disorder, bipolar disorder (BD), major depressive disorder, and schizophrenia, including first-episode psychosis. We included meta-analyses that compared alterations in peripheral biomarkers between participants with mental disorders to controls (i.e., between-group meta-analyses) and that assessed biomarkers after treatment (i.e., within-group meta-analyses). Evidence for association was hierarchically graded using a priori defined criteria against several biases. The Assessment of Multiple Systematic Reviews (AMSTAR) instrument was used to investigate study quality. 1161 references were screened. 110 met inclusion criteria, relating to 359 meta-analytic estimates and 733,316 measurements, on 162 different biomarkers. Only two estimates met a priori defined criteria for convincing evidence (elevated awakening cortisol levels in euthymic BD participants relative to controls and decreased pyridoxal levels in participants with schizophrenia relative to controls). Of 42 estimates which met criteria for highly suggestive evidence only five biomarker aberrations occurred in more than one disorder. Only 15 meta-analyses had a power >0.8 to detect a small effect size, and most (81.9%) meta-analyses had high heterogeneity. Although some associations met criteria for either convincing or highly suggestive evidence, overall the vast literature of peripheral biomarkers for major mental disorders is affected by bias and is underpowered. No convincing evidence supported the existence of a trans-diagnostic biomarker. Adequately powered and methodologically sound future large collaborative studies are warranted.

Item Type: Journal Article
Keywords: Peripheral Biomarkers, Major Mental Disorders, Umbrella Review
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 04 May 2020 09:10
Last Modified: 20 Oct 2021 08:23
URI: https://arro.anglia.ac.uk/id/eprint/705468

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