Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature

Veronese, Nicola and Demurtas, Jacopo and Yang, Lin and Tonelli, Roberto and Barbagallo, Mario and Lopalco, Pierluigi and Lagolio, Erik and Celotto, Stefano and Pizzol, Damiano and Zou, Liye and Tully, Mark A. and Ilie, Petre and Trorr, Mike and López Sánchez, Guillermo F. and Smith, Lee (2020) Use of Corticosteroids in Coronavirus Disease 2019 Pneumonia: A Systematic Review of the Literature. Frontiers in Medicine, 7. p. 170. ISSN 2296-858X

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Official URL: https://doi.org/10.3389/fmed.2020.00170

Abstract

The aim was to investigate the effectiveness of glucocorticoid therapy in patients with COVID-19. A systematic search of the literature across nine databases was conducted from inception until 15th March 2020, following the PRISMA guidelines. Patients with a validated diagnosis of COVID-19 and using corticosteroids were included, considering all health outcomes. Four studies with 542 Chinese participants were included. Two studies reported negative findings regarding the use of corticosteroids in patients with COVID-19, i.e., corticosteroids had a detrimental impact on clinical outcomes. One study reported no significant association between the use of corticosteroids and clinical outcomes. However, one study, on 201 participants with different stages of pneumonia due to COVID-19, found that in more severe forms, the administration of methylprednisolone significantly reduced the risk of death by 62%. The literature to date does not fully support the routine use of corticosteroids in COVID-19, but some findings suggest that methylprednisolone could lower mortality rate in more severe forms of the condition.

Item Type: Journal Article
Keywords: COVID-19, coronavirus, corticosteroids, methylprednisolone, pneumonia, ARDS, SARS-Cov-2
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 15 Apr 2020 13:43
Last Modified: 15 May 2020 13:33
URI: http://arro.anglia.ac.uk/id/eprint/705418

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