Prevalence of erectile dysfunction in patients with chronic kidney disease: a systematic review and meta-analysis

Pizzol, Damiano and Xiao, Tao and Yang, Lin and Demurtas, Jacopo and McDermott, Daragh T. and Garolla, Andrea and Nardelotto, Antonella and Grabovac, Igor and Soysal, Pinar and Kazancioglu, Rumeyza and Veronese, Nicola and Smith, Lee (2020) Prevalence of erectile dysfunction in patients with chronic kidney disease: a systematic review and meta-analysis. International Journal of Impotence Research, 150 (7). pp. 1909-1915. ISSN 1476-5489

[img] Text
Accepted Version
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (10MB)
Official URL:


Growing evidence reports that chronic kidney diseases (CKD) might play a role in erectile dysfunction (ED), but limited knowledge is available. Therefore, we performed a systematic review up to 21/08/2019 to investigate the associations between CKD and ED. The main analysis reported the prevalence of ED as absolute estimates (in %) with their 95% confidence intervals (CIs) and across CKD stages (when specified), hemodialysis and transplant, calculating the p for interaction across strata. Among 291 studies, we included 34 articles with 5986 men. We found an overall prevalence of 76% (95%CI: 72–79) with a high degree of heterogeneity (I2 = 84.2%; p < 0.0001). Analyzing the data by CKD stage, we found a significant higher prevalence of ED in CKD (78%; 95%CI: 75–81%; I2 = not possible) compared with hemodialysis stage (prevalence = 77%; 95%CI: 73–80%; I2 = 84.5) or to patients undergoing transplant (prevalence = 64%; 95%CI: 54–74%; I2 = 54%) (p across strata = 0.036). Considering the high prevalence of ED in men with CKD, health care practitioners should focus on issues of sexual health in men with CKD. Given the advancements in dialysis and therapy and the associated advancements in survival and life expectancy, maintaining the patients’ sexual function is important for their well-being and quality of life.

Item Type: Journal Article
Keywords: CKD, Erectile Dysfunction, Meta-analyses
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 07 Apr 2020 10:51
Last Modified: 09 Sep 2021 18:52

Actions (login required)

Edit Item Edit Item