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Prevalence of erectile dysfunction in patients with chronic kidney disease: a systematic review and meta-analysis

journal contribution
posted on 2023-08-30, 17:07 authored by Damiano Pizzol, Tao Xiao, Lin Yang, Jacopo Demurtas, Daragh T. McDermott, Andrea Garolla, Antonella Nardelotto, Igor Grabovac, Pinar Soysal, Rumeyza Kazancioglu, Nicola Veronese, Lee Smith
Growing evidence reports that chronic kidney diseases (CKD) might play a role in erectile dysfunction (ED), but limited knowledge is available. Therefore, we performed a systematic review up to 21/08/2019 to investigate the associations between CKD and ED. The main analysis reported the prevalence of ED as absolute estimates (in %) with their 95% confidence intervals (CIs) and across CKD stages (when specified), hemodialysis and transplant, calculating the p for interaction across strata. Among 291 studies, we included 34 articles with 5986 men. We found an overall prevalence of 76% (95%CI: 72–79) with a high degree of heterogeneity (I2 = 84.2%; p < 0.0001). Analyzing the data by CKD stage, we found a significant higher prevalence of ED in CKD (78%; 95%CI: 75–81%; I2 = not possible) compared with hemodialysis stage (prevalence = 77%; 95%CI: 73–80%; I2 = 84.5) or to patients undergoing transplant (prevalence = 64%; 95%CI: 54–74%; I2 = 54%) (p across strata = 0.036). Considering the high prevalence of ED in men with CKD, health care practitioners should focus on issues of sexual health in men with CKD. Given the advancements in dialysis and therapy and the associated advancements in survival and life expectancy, maintaining the patients’ sexual function is important for their well-being and quality of life.

History

Refereed

  • Yes

Volume

150

Issue number

7

Page range

1909-1915

Publication title

International Journal of Impotence Research

ISSN

1476-5489

Publisher

Springer

File version

  • Accepted version

Language

  • eng

Legacy posted date

2020-04-07

Legacy creation date

2020-04-07

Legacy Faculty/School/Department

Faculty of Science & Engineering

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