Relationship between sarcopenia and orthostatic hypotension

Soysal, Pinar and Kocyigit, Suleyman E. and Dokuzlar, Ozge and Bulut, Esra and Smith, Lee and Isik, Ahmet T. (2020) Relationship between sarcopenia and orthostatic hypotension. Age and Ageing. ISSN 1468-2834

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Official URL: https://doi.org/10.1093/ageing/afaa077

Abstract

Background: The relationship between sarcopenia and orthostatic hypotension (OH) is unclear. Objectives: The aim of the present study was to investigate associations between sarcopenia/sarcopenia severity and OH. Design: 511 patients attending a geriatric outpatient clinic were included. OH was defined as a decrease in systolic and/or diastolic blood pressure of ≥20 mmHg and/or ≥10 mmHg, respectively, when one transitions from the supine to an upright position. OH was measured by the Head-up Tilt Table test at 1, 3, and 5 minutes (OH1, OH3, and OH5, respectively). Sarcopenia and severity were defined according to the revised European consensus on definition and diagnosis. Results:The mean age of the sample was 75.40±7.35 years and 69.9% were female.The prevalence of probable sarcopenia, sarcopenia and severe sarcopenia was 42.2%, 6.06% and 11.1%, respectively. After adjustment for all covariates, systolic OH1, OH1 and systolic OH5 were statistically significant between severe sarcopenia and the robust group (Odd Ratio (OR):3.26 Confidence Interval [CI] 0.98-10.84; p=0.05 for systolic OH1, OR:4.31 CI 1.31-14.15; p=0.016 for OH1, OR:4.09 CI 1.01-16.55; p=0.048 for systolic OH5). Only systolic OH1 was statistically different between sarcopenia and severe sarcopenia groups (OR:2.64 CI; 1.87-8.73; p=0.012). OH1 and OH5 were statistically significant between severe sarcopenia and probable sarcopenia groups (p<0.05), there was no relationship between the robust group and probable sarcopenia (p>0.05). Conclusions: There is a close relationship between sarcopenia and severe sarcopenia and OH in older adults. Therefore, when a healthcare practitioner is evaluating an older patient with sarcopenia, OH should also be evaluated and vice versa.

Item Type: Journal Article
Keywords: sarcopenia, orthostatic hypotension, geriatric assessment
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 24 Mar 2020 14:06
Last Modified: 20 Jul 2020 11:39
URI: http://arro.anglia.ac.uk/id/eprint/705347

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