Cross-sectional associations between Angiotensin Converting Enzyme inhibitor use and cancer diagnosis in US adults

Smith, Lee and Parris, Christopher N. and Veronese, Nicola and Shang, Ce and López Sánchez, Guillermo F. and Jacob, Louis and Koyanagi, Ai and Nottegar, Alessia and Jackson, Sarah E. and Raupach, Tobias and Grabovac, Igor and Crichton, Scott and Dempsey, Fiona and Yang, Lin (2020) Cross-sectional associations between Angiotensin Converting Enzyme inhibitor use and cancer diagnosis in US adults. Clinical and Experimental Medicine, 20. pp. 409-416. ISSN 1591-9528

[img] Text
Accepted Version
Restricted to Repository staff only until 26 March 2021.
Available under the following license: Creative Commons Attribution Non-commercial No Derivatives.

Download (67kB) | Request a copy
Official URL: https://doi.org/10.1007/s10238-020-00622-7

Abstract

Purpose: The objective of the present study was to investigate the association between Angiotensin converting enzyme (ACE) inhibitor use and cancer incidence (overall, and breast, prostate, and colorectal cancers specifically) in a large representative sample of US adults. Methods: Cross-sectional data on cancer diagnosis, timing of cancer diagnosis, ACE inhibitor use, and other characteristics were extracted from 49 512 adults aged ≥ 20 years participating in the National Health and Nutrition Examination Survey (1999-2016). Multivariable-logistic and propensity score matching (PSM) regressions examined the relationship between pre-diagnosis use of ACE inhibitors and diagnosis of all cancers, and breast, prostate, and colorectal cancers specifically. Results: Overall, we observed an increased likelihood of cancer diagnosis [odds ratio (OR)=1.269, 95% confidence interval (CI): 1.088 to 1.480] among those who used ACE inhibitors compared to non-ACE inhibitor use, and for prostate cancer diagnosis (OR=1.438, 95% CI: 1.090 to 1.897), after adjusting for age, sex, body mass index, race/ethnicity, educational attainment, physical activity, alcohol drinking status, smoking status, and high blood pressure. PSM regression retrieved more conservative estimates such that the increased likelihood of cancer diagnosis was only observed when comparing ACE inhibitor users with non-drug users (OR=1.022, 95% CI: 1.016 to 1.027). Conclusion: Compared with non-ACE inhibitor use, ACE inhibitor use was associated with an increased risk of prostate cancer. In conclusion, in this large representative sample of US adults, it was found that ACE inhibitor use may have a marginal influence on some cancers.

Item Type: Journal Article
Keywords: Angiotensin converting enzyme inhibitors, Cancer, NHANES, Epidemiology, Observational
Faculty: Faculty of Science & Engineering
SWORD Depositor: Symplectic User
Depositing User: Symplectic User
Date Deposited: 18 Mar 2020 09:57
Last Modified: 03 Sep 2020 14:06
URI: http://arro.anglia.ac.uk/id/eprint/705314

Actions (login required)

Edit Item Edit Item